Our Research

Our lab investigates the critical roles of microglia in brain health and disease, with a focus on functional recovery and neural circuit remodeling. In collaboration with Dr. Nicholas Sibinga and Dr. Pablo Castillo of Albert Einstein College of Medicine, we explored the role of IBA1 (Ionized Calcium-Binding Adapter Molecule 1), a protein widely recognized as a microglial marker.

Our study revealed that while IBA1 is essential for microglial structure and function, its deletion leads to significant impairments in synaptic development and behavior. These findings highlight IBA1’s previously unrecognized role in maintaining microglial health and underscore the potential of targeting microglial pathways as a therapeutic strategy for neurodevelopmental and neurodegenerative disorders.

PubMed

Neural Circuit Remodeling

Microglia, the resident immune cells of the brain, play a pivotal role in shaping neural circuits. These dynamic cells actively survey their environment, removing excess synapses during development and maintaining synaptic integrity in adulthood. Our lab investigates how microglia contribute to neural circuit remodeling in both healthy and diseased states. Using advanced imaging techniques and molecular tools, we study the mechanisms by which microglia interact with neurons to regulate synaptic pruning, plasticity, and connectivity. Understanding these processes can provide insights into neurodevelopmental disorders and age-related cognitive decline, where microglial dysfunction may disrupt normal neural circuit dynamics.

Neural Injury and Recovery

In the aftermath of neural injury, microglia are among the first responders, orchestrating the brain’s repair mechanisms. Our research explores the dual role of microglia in neural recovery—promoting repair by clearing debris and modulating inflammation, while also potentially exacerbating damage if improperly activated. Through mouse models such as and stroke, we investigate how microglia influence synaptic regeneration and functional recovery. By identifying pathways that enhance the beneficial effects of microglia and mitigate their harmful responses, we aim to uncover therapeutic targets for improving outcomes after neural injury.